منابع مشابه
Mycophenolic acid is a new Nox2 inhibitor.
Organ transplantation owes its spectacular development in recent decades to the introduction of immunosuppressive drugs capable of preventing allograft rejection. However, vasculopathy remains a major cause of long-term graft failure; thus, a better understanding of its mechanisms is required to improve tolerance. Because endothelial dysfunction is an early manifestation of vascular disorders, ...
متن کاملMycophenolic acid is a potent inhibitor of angiogenesis.
Angiogenesis is necessary for the vascularization of a tumor, providing essential nourishment for tumor growth, and the progression and metastasis of cancer cells.1 Although tremendous efforts and resources have been dedicated to discovering angiogenesis inhibitors, very few candidates have been approved by FDA for therapeutic applications. Currently, Avastin (bevacizumab), a humanized monoclon...
متن کاملAssessment of mycophenolic acid-induced immunosuppression: a new approach.
BACKGROUND Mycophenolic acid (MPA), a metabolite of mycophenolate mofetil (MMF), is an immunosuppressive agent that inhibits inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the ex novo synthesis of GTP. We measured IMPDH activity in peripheral blood mononuclear cells (PBMCs) from MMF-treated patients to evaluate the efficacy of MMF in individual patients. METHODS IMPDH activity w...
متن کاملMycophenolic acid in silage.
We examined 233 silage samples and found that molds were present in 206 samples with counts between 1 x 10(3) and 8.9 x 10(7) (mean, 4.7 x 10(6)) CFU/g. Mycophenolic acid, a metabolite of Penicillium roqueforti, was detected by liquid chromatography-mass spectrometry in 74 (32%) of these samples at levels ranging from 20 to 35,000 (mean, 1,400) microg/kg. This compound has well-known immunosupp...
متن کاملAntitumor activity of mycophenolic acid.
n our laboratory in 4CS mice. (3) Mouse ascites hepatoma, MH134, was converted into ascitic form by Sato et al.*\ from a C3H/HeN mouse hapatoma induced after treatment with carbon tetrachloride by Andervont et al.5) It has been maintained in C3H/He mice with distinct strain specificity in tumor take in our laboratory. (4) Mouse ascites sarcoma, SR-C3H/He Th62, was originally induced with Schmid...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2007
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000251161.93696.d0